Medicinal Mushroom Hot Water Extract vs. Alcohol Extract

By Dr. Markho Rafael

Medicinal mushrooms have been immensely popular in Asia for millennia. Today, Americans are waking up to these powerful nutraceuticals. In the wake of this new awareness follow issues of product quality claims made by competing brands.

All medicinal mushroom species are plagued by this. Most fiercely debated is red reishi (Ganoderma lucidum), the most popular of all medicinal mushrooms. So this article will primarily focus on that species, but it's generally applicable to all species of medicinal mushrooms.

First off, stay clear of cheap, mass-produced medicinal mushrooms. If they are just dried and pulverized, then the medicinal compounds are still inaccessible behind the mushrooms' cell-walls. You'll be wasting your money on inert matter.

Then there are the real therapeutic grade red reishi brands, which are produced with much more care. But even here there are big differences between brands. Each claims to be the best, of course, because they want to sell their product. So lets set the facts straight and be independently informed consumers.

There are primarily three ways to extract the medicinal compounds from red reishi. Each method pulls out different compounds, all of which have been proven by scientific research to be therapeutically important.

1. Water Extraction, Hot (polysaccharides and more)

2. Alcohol Extraction (triterpenoids, sterols)

3. Fermented (arabinoxylanes, etc.)

The water soluble compounds, primarily polysaccharides, are powerful anti-tumor agents, immune enhancers and strong antioxidants. [1]

The alcohol soluble compounds are mainly triterpenoids, a large group of related compounds. Scientific studies suggest they help stabilize cholesterol, blood pressure and clotting. Most importantly, they are the anti-inflammatory compounds so critical to many of reishi's suggested uses, including arthritis, allergies and asthma. [1]

Finally, by fermenting the red reishi, the original medicinal compounds break down to form new compounds with unique healing properties. These "secondary metabolites" have among other things been shown to be immune enhancing and help regulate blood sugar, as well as having unique anti-tumor properties. [2]

Since this article is not intended to elevate any one brand over another, no brand names will be mentioned. Nevertheless, the author does know of two highly reputed brands (American and Japanese) that claim only hot water extracted red reishi is of any value and that alcohol extracts are useless.

Of course they do that to promote their own brand. In reality both hot water extract and alcohol extract contain unique medicinal compounds that are all very important.

When looking for the best reishi extract, find one that uses at least the first two extraction methods in combination: Hot Water and Alcohol Extraction. Even better may be a brand that includes all three methods listed.

An additional point to keep in mind is the form the reishi comes in. Reishi that dissolves completely in a water-based liquid such as coffee probably only contains reishi from hot water extraction. As a substitute for regular coffee, this would be a superb health-choice. However, it will not contain the water-insoluble triterpenoids so valued for their anti-inflammatory properties.

On the other hand, alcohol tinctures can actually contain both water soluble polysaccharides and alcohol soluble triterpenoids. The way you know is that the polysaccharides will fall out of solution because of the alcohol, and will make the tincture cloudy. That's alright though; you just need to shake before you take. Capsules and tablets may be one or the other or both. The only way to know is ask the manufacturer or read their information.

[1] Boh B, Berovic M, Zhang J, Zhi-Bin L. "Ganoderma lucidum and its pharmaceutically active compounds." Biotechnol Annu Rev. 2007;13:265-301.

[2] Tang YJ, Zhang W, Zhong JJ. "Performance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum." Bioresour Technol. 2009 Mar;100(5):1852-9. - 30287

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